Effect of inflammation on the corneal endothelial pump and barrier
作者:
MacdonaldJoan M.,
GeroskiDayle H.,
EdelhauserHenry F.,
期刊:
Current Eye Research
(Taylor Available online 1987)
卷期:
Volume 6,
issue 9
页码: 1125-1132
ISSN:0271-3683
年代: 1987
DOI:10.3109/02713688709034885
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Corneal thickness is a reflection of endothelial barrier and pump functions. The corneal edema that occurs during intraocular inflammation is a consequence of the breakdown of one or both of these parameters. Results of this study demonstrate that, during intraocular inflammation induced by an intra-vitreal injection of bovine serum albumin (BSA), the permeability of rabbit corneal endothelia to inulin was increased. By comparison, treatment with oral aspirin and/or subconjunctival triamcinolone acetonide prevented the endothelial barrier breakdown induced by the BSA. Concomitant with the loss of the barrier function, endothelial ouabain binding decreased in the BSA injected eye, indicating a reduction in endothelial Na/K ATPase pump site density. A subconjunctival injection of triamcinolone prevented this decrease in pump sites. The increase in endotheliai permeability and the decrease in pump site density correlated with an increase in corneal thickness. It can be concluded that the intraocular inflammation induced by BSA effects corneal edema by both an increase in endothelial permeability and a decrease in Na/K ATPase pump site density. Subconjunctival triamcinolone is effective in preventing this response.
点击下载:
PDF (703KB)
返 回