Oxidants, inflammation, and anti‐inflammatory drugs
作者:
Barry Halliwell,
J. Robin Hoult,
David R. Blake,
期刊:
The FASEB Journal
(WILEY Available online 1988)
卷期:
Volume 2,
issue 13
页码: 2867-2873
ISSN:0892-6638
年代: 1988
DOI:10.1096/fasebj.2.13.2844616
出版商: Wiley
数据来源: WILEY
摘要:
Species such as superoxide radical (O2−), hydrogen peroxide (H2O2), hydroxyl radical (·OH), and hypochlorous acid (HOC1) can be formed in vivo, e.g., by activated phagocytic cells. Generation of·OH from H2O2in vivo usually involves iron‐dependent reactions. Good evidence exists for increased generation of oxidants in vivo in patients with active rheumatoid disease, but the contribution of these oxidants to the disease process is still uncertain. The likelihood that anti‐inflammatory drugs used in the treatment of arthritis could act by scavenging oxidants or preventing their formation is discussed.— Halliwell, B.; Hoult, J. R.; Blake, D. R. Oxidants, inflammation, and anti‐inflammatory drugs.FASEB J.2: 2867‐2873; 1988.
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