Defective Pancreatic Alpha and Beta Cell Secretion in Thyrotoxicosis
作者:
THEODORE AVRUSKIN,
MARIO BRAKIN,
VINOD LALA,
CHRISTINA JUAN,
期刊:
The American Journal of the Medical Sciences
(OVID Available online 1985)
卷期:
Volume 290,
issue 5
页码: 179-184
ISSN:0002-9629
年代: 1985
出版商: OVID
关键词: Thyrotoxicosis;Insulin secretion;carbohydrate metabolism;Glucagon secretion
数据来源: OVID
摘要:
Pancreatic alpha and beta cell hormone secretion was studied in 11 patients with thyrotoxicosis before and in 7 patients after thyroid function was normalized with either prophylthiouracil or methimazole and propranolol (R). All had IV arginine and IV glucose infusions. Forty control subjects had IV arginine; 21 had IV glucose tests. After arginine, untreated patient had blunted serum insulin at both 15 and 30 minutes (p<0.05, p<0.001) compared to control subjects, blunted glucagon at 30 minutes (p<0.05) and blunted glucose at both 15 and 30 minutes (p<0.001, p<0.01) compared to control subjects. After glucose, untreated patients had lower nadir glucagon than in the studies with both arginine and glucose infusions. These data document blunted glucagon, suppressed glucose and insulin peaks after arginine in thyrotoxicosis, indicate that both alpha and beta cell hormone secretion may be abnormal, and that the preferential abnormality follows protein rather than carbohydrate loading.
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