Infectious complications of purine analog therapy
作者:
George Samonis,
Dimitrios Kontoyiannis,
期刊:
Current Opinion in Infectious Diseases
(OVID Available online 2001)
卷期:
Volume 14,
issue 4
页码: 409-413
ISSN:0951-7375
年代: 2001
出版商: OVID
数据来源: OVID
摘要:
Patients with lymphoid malignancies such as chronic lymphocytic leukemia, particularly those who receive the newer purine analogs, are at increased risk for infectious morbidity and mortality. Defects in cell-mediated immunity appear to be a major predisposing factor in these patients. An expanding spectrum of pathogens associated with lymphocytopenia and depletion of CD4 has been described in the setting of therapy with purine analogs. During the past 2 years new knowledge about the immunosuppression related to that treatment has continued to accumulate.
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