Two Quantitative Trait Loci Affect ACE Activities in Mexican-Americans
作者:
Candace Kammerer,
Nicolas Gouin,
Paul Samollow,
Jane VandeBerg,
James Hixson,
Shelley Cole,
Jean MacCluer,
Larry Atwood,
期刊:
Hypertension: Journal of The American Heart Association
(OVID Available online 2004)
卷期:
Volume 43,
issue 2, Part 2
页码: 466-470
ISSN:0194-911X
年代: 2004
出版商: OVID
关键词: ethnic groups;blood pressure;genetics;hypertension, genetic
数据来源: OVID
摘要:
Abstract—Angiotensin-converting enzyme (ACE) activity is highly heritable and has been associated with cardiovascular disease. We are studying the effects of genes and environmental factors on hypertension and related phenotypes, such as ACE activity, in Mexican-American families. In the current study, we performed multipoint linkage analysis to search for quantitative trait loci (QTLs) that affect ACE activities on data from 793 individuals from 29 pedigrees from the San Antonio Family Heart Study. As expected, we obtained strong evidence (maximum log of the odds [LOD]=4.57, genomicP=0.003) that a QTL for ACE activity is located on chromosome 17 near theACEstructural locus. We subsequently performed linkage analyses conditional on the effect of this QTL and obtained strong evidence (LOD=3.34) for a second QTL on chromosome 4 near D4S1548. We next incorporated theACEIns/Delgenotypes in our analyses and removed the evidence for the chromosome 17 QTL (maximum LOD=0.60); however, we retained our evidence for the QTL on chromosome 4q. We conclude that the QTL on chromosome 17 is tightly linked toACEand is in strong disequilibrium with the insertion/deletion polymorphism, which is consistent with other reports. We also have evidence that an additional QTL affects ACE activity. Identification of this additional QTL might lead to alternate means of prophylaxis.
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