Effect of Sodium Deficiency on Cochlear Potentials
作者:
Teruzo Konishi,
Elizabeth Kelsey,
期刊:
The Journal of the Acoustical Society of America
(AIP Available online 1968)
卷期:
Volume 43,
issue 3
页码: 462-470
ISSN:0001-4966
年代: 1968
DOI:10.1121/1.1910853
出版商: Acoustical Society of America
数据来源: AIP
摘要:
The scala tympani in guinea pigs was prefused with mammalian Ringer‐Locke's solution, in which NaCl was replaced with either choline chloride or sucrose. Cochlear potentials were recorded from the basal turn before, during, and subsequent to the perfusion. Complete replacement of the perilymph withNa+‐free solution did not alter the endocochlear potential and the cochlear microphonic immediately, although the action potential was abolished rapidly. In most cases, the depression of the action potential was reversible. The mechanism underlying the generation of the receptor potential is discussed, and it is concluded that production of cochlear microphonic is not dependent on the concentration ofNa+in the perilymph but on the presence of highK+concentration in the endolymph.
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