Effect of covariate measurement error in randomized clinical trials
作者:
Timothy M. Morgan,
Robert M. Elashoff,
期刊:
Statistics in Medicine
(WILEY Available online 1987)
卷期:
Volume 6,
issue 1
页码: 31-41
ISSN:0277-6715
年代: 1987
DOI:10.1002/sim.4780060105
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: Measurement error;Clinical trials;Covariates Efficiency
数据来源: WILEY
摘要:
AbstractPrognostic factors often appear as covariates in clinical trials designed to estimate treatment effects. These factors are usually subject to measurement error and lead to decreased efficiency in the estimation of the treatment effect. We use Weibull regression models and asymptotic theory to derive the efficiency of estimation obtained by adjusting for one dichotomous and one continuous covariate measured with error. An application to a clinical trial involving advanced lung cancer patients illustrates the results.
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