Radiofrequency Hyperthermia and Topical Retinoic Acid Therapy in Murine Melanoma
作者:
NORMAN LEVINE,
SCOTT DON,
SCOTT KLEWER,
JUAN VASQUEZ,
ZOE DRAELOS,
期刊:
The American Journal of the Medical Sciences
(OVID Available online 1989)
卷期:
Volume 297,
issue 5
页码: 285-289
ISSN:0002-9629
年代: 1989
出版商: OVID
关键词: Hyperthermia;Retinoids;Melanoma
数据来源: OVID
摘要:
Milignant cells are known to be sensitive to increased temperature. The effects of hyperthermia (HT) on intradermally implanted S91 melanoma cells in syngeneic mice were investigated with a hand-held radiofrequency generator. The possible additive effects of topical retinoic acid (RA) in this system also were studied. Five millimeter diameter melanomas were treated with either HT alone, RA alone, or a combination of HT and RA and were then evaluated after 43 days and 59 days. Eighteen of 20 tumors treated with HT alone and all l20 melanomas treated with HT/RA were eradicated. RA alone caused complete regression in 11 of 19 treated tumors. It is concluded that radiofrequency HT is an effective treatment in intradermal murine melanoma and that the additions of RA does not significantly alter the outcome because of the extreme effectiveness of HT alone.
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