Low‐dose cytosine arabinoside for treating hypocellular acute leukemia in the elderly
作者:
Heiwa Kanamori,
Atsuo Maruta,
Hiroko Miyashita,
Hiroshi Harano,
Hitoshi Fukawa,
Michio Matsuzaki,
Shigeki Motomura,
Hiroshi Mohri,
Fumio Kodama,
Takao Okubo,
期刊:
American Journal of Hematology
(WILEY Available online 1992)
卷期:
Volume 39,
issue 1
页码: 52-55
ISSN:0361-8609
年代: 1992
DOI:10.1002/ajh.2830390111
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: low‐dose cytosine arabinoside;hypocellular acute leukemia;elderly patients
数据来源: WILEY
摘要:
AbstractTen previously untreated elderly patients with hypocellular acute leukemia received a low dose of cytosine arabinoside (Ara‐C), 10 mg/m2injected subcutaneously every 12 hours for 14‐28 days. Six patients achieved a complete remission (CR) for periods ranging for 6‐23 months (median 8.5 months) and the others had a partial remission (PR). Relapse has occurred in three patients to date. The median survival ranged from 10‐24 months (median 14.5 months). Only two of the six patients, in whom bone marrow biopsy was performed at CR, had a normal cellularity. This change, however, did not appear to be a significant prognostic factor in those patients. In seven patients who achieved a CR or PR low‐dose Ara‐C was administrated as maintenance therapy at the same low dose for 10 days each month. Treatment was well tolerated in all patients despite for myelosuppression. There were no drug‐related deaths. These observations suggest that low‐dose Ara‐C is effective in treating elderly patients with hypocellul
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