On the Presence of a MSH-Release Inhibiting System in the Rat Neurointermediate Lobe
作者:
F.J.H. Tilders,
A.H. Mulder,
P.G. Smelik,
期刊:
Neuroendocrinology
(Karger Available online 1975)
卷期:
Volume 18,
issue 1
页码: 125-130
ISSN:0028-3835
年代: 1975
DOI:10.1159/000122390
出版商: S. Karger AG
关键词: Control of MSH;Intermediate lobe;Dopamine
数据来源: Karger
摘要:
Rat neurointermediate lobes were superfused in vitro and showed a stable secretion rate of MSH after 30 min. MSH secretion from lobes of untreated rats was reversibly inhibited during superfusion with medium containing 45 mM K+. This inhibition could not be induced using lobes from median eminence lesioned or reserpinized rats. Superfusion with 45 mM K+ also induced release of dopamine from lobes preincubated with the labeled transmitter. It is concluded that the MSH-release inhibiting system present in the rat neurointermediate lobe may be identical to the dopaminergic arcuate-intermediate lobe system.
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