The article reports a study describing nurses' attitudes, concerns, and fear of acquired immunodeficiency syndrome (AIDS). A convenience sample consisting of 376 nurses in a mid-Atlantic state was drawn. An 84- item questionnaire was used to collect the data. Seven factors were derived from the subjects' responses using the Fear of AIDS Scale II: opinion and AIDS policy, blood and physical closeness to patients with AIDS, punishing the homosexual, ethics of care, “Who would care for me?,” financial burden, and self-worth. Fear of AIDS Scale II scores ranked the highest whenever “self” was involved with AIDS issues or blood and physical closeness to a person with AIDS. There was a parallel increasing relationship between concern about contracting AIDS from patients and the fear of AIDS. A number of other significant correlations emerged from the study.