The Next Wave of AnticonvulsantsFocus on Levetiracetam, Oxcarbazepine and Zonisamide
作者:
Steven C. Schachter,
期刊:
CNS Drugs
(ADIS Available online 2000)
卷期:
Volume 14,
issue 3
页码: 229-249
ISSN:1172-7047
年代: 2000
出版商: ADIS
关键词: Anticonvulsants, therapeutic use;Epilepsy, treatment;Levetiracetam, general;Oxcarbazepine, general;Research and development;Zonisamide, general
数据来源: ADIS
摘要:
Since December 1999, 3 drugs have been cleared for marketing by the US Food and Drug Administration for the treatment of partial-onset seizures in adults with epilepsy − levetiracetam, oxcarbazepine and zonisamide. All are approved as adjunctive therapy; oxcarbazepine is also approved as monotherapy. Levetiracetam appears to have a novel mechanism of action, while the others block voltage-sensitive sodium channels (oxcarbazepine and zonisamide) and T-type calcium channels (zonisamide). Levetiracetam and oxcarbazepine have short serum elimination half-lives and can be started at therapeutic dosages. All 3 drugs exhibit linear pharmacokinetics and have a low propensity for drug-drug interactions. There is extensive worldwide experience with oxcarbazepine and zonisamide, whereas exposure to levetiracetam has been limited to a relatively small number of patients in clinical trials.These 3 drugs are important additions to the armamentarium for the treatment of seizures and offer patients whose lives are compromised by epilepsy the potential to achieve a better quality of life.
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