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MP17, a fiber-specific intrinsic membrane protein from mammalian eye lens

 

作者: MuldersJohn W.M.,   VoorterChristina E.M.,   LamersCor,   de HaardWilleke A.,   MontecuccoCesare,   van de VenWim J.M.,   BloemendalHans,   de JongWilfried W.,  

 

期刊: Current Eye Research  （Taylor Available online 1988）
卷期: Volume 7, issue 2  

页码: 207-219

 

ISSN:0271-3683

 

年代: 1988

 

DOI:10.3109/02713688808995750

 

出版商: Taylor&Francis

 

数据来源: Taylor

 

摘要:

A major protein with a molecular weight of 17,000, designated as MP17, has been identified in mammalian eye lens plasma membranes. Hydrophobic photolabeling experiments revealed that MP17 is a genuine intrinsic membrane protein. By using monoclonal antibodies we demonstrated that MP17 is not detectable in liver, heart, muscle, spleen and kidney, and thus can be considered, like MP26, as a lens-specific membrane protein. Furthermore, we showed that MP17 is a substrate for cAMP-dependent protein kinase and that it is a calmodulin-binding protein.

 

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