Cognitive Behavior in Heredodegenerative Ataxias
作者:
Thèrése Botez-Marquard,
M.I. Botez,
期刊:
European Neurology
(Karger Available online 1993)
卷期:
Volume 33,
issue 5
页码: 351-357
ISSN:0014-3022
年代: 1993
DOI:10.1159/000116970
出版商: S. Karger AG
关键词: Cognition;Cerebellum;Reaction time;Friedreich’s ataxia;Olivopontocerebellar atrophy;Raven’s standard progressive matrices
数据来源: Karger
摘要:
Fifteen patients with Friedreich’s ataxia (FA) and 15 others with olivopontocerebellar atrophy (OPCA) were evaluated with a comprehensive neuropsychological battery of tests. They were pair-matched with normal controls for age, sex and education. Depressed patients were excluded from the study as were those with extrapyramidal signs. The following results were obtained: (1) the Raven test, untimed block design performance in OPCA and quantitative analysis of Rey figure drawing revealed a visuospatial deficit suggestive of a mild parietal-like syndrome; signs of mild frontal-like syndrome were also found; (2) cognition was slowed in the FA group; (3) simple visual and auditory reaction times were increased in both patient groups. It appears that the cerebellum may interfere indirectly with cognition through various physiological and neurochemical 2-way cerebellocortical loops. Finally, the cerebellum seems to interfere directly also with basic speed of information processin
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