Synergistic Effect between Intraneoplastic Methotrexate and Radiation on Experimental Intracerebral Rat Gliosarcoma
作者:
Harold Wilkinson,
Takashi Fujiwara,
Steven Rosenfeld,
期刊:
Neurosurgery
(OVID Available online 1994)
卷期:
Volume 34,
issue 4
页码: 665-668
ISSN:0148-396X
年代: 1994
出版商: OVID
关键词: Brain tumors;Chemotherapy;Intraneoplastic therapy;Radiation therapy;RT-9 gliosarcoma
数据来源: OVID
摘要:
METHOTREXATE (MTX) ALONE has a limited effect against malignant brain tumors, but we previously demonstrated a beneficial synergism between MTX and radiation therapy (XRT) against RT-9 gliosarcoma. Because the beneficial effects of that study were limited by systemic toxicity and poor brain penetration of MTX, we have continued our studies using direct intracerebral MTX therapy. Male CD-Fisher rats with intracerebrally implanted RT-9 gliosarcoma and indwelling brain tumor catheters were treated with intracerebral injections of MTX, whole-brain XRT, or a combination of both. MTX was given either as one of two “high-dose” treatments, on the basis of whole-body doses, or two “low-doses,” on the basis of average brain weight. MTX alone at lower doses and XRT alone each prolonged survival moderately. High-dose MTX was highly toxic, but low-dose MTX was well tolerated. Combined MTX and XRT caused a significant prolongation of survival in all animals that survived treatment long enough to die from tumor growth.
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