Synthesis and cytogenetic effects of aminoquinone derivatives with a di- and a tripeptide
作者:
Ch Pachatouridis,
Z Iakovidou,
E Myoglou,
D Mourelatos,
AA Pantazaki,
VP Papageorgiou,
A Kotsis,
M Liakopoulou-Kyriakides,
期刊:
Anti-Cancer Drugs
(OVID Available online 2002)
卷期:
Volume 13,
issue 4
页码: 367-372
ISSN:0959-4973
年代: 2002
出版商: OVID
关键词: Biological activity;cytostatic;cytotoxic;derivatives of aminoquinones with peptides;enzymic effect
数据来源: OVID
摘要:
Quinones are of significant interest due to their important role in specific cellular functions. Quinoproteins are a big class of oxyreductative agents occurring in bacteria and other organisms. In this investigation derivatives of 2-amino-1,4-benzoquinone, 2-amino-1,4-naphthoquinone and 2-amino-5,8-dihydroxy-1,4-naphthoquinone with a di- and a tripeptide were prepared for first time. The effect of the synthesized compounds on sister chomatid exchange (SCE) rates and human lymphocyte proliferation kinetics on a molar basis was studied. Among these coupled products the most effective in inducing SCEs and depressing proliferation rate indices is the coupling product of 2-amino-1,4-naphthoquinone with the tripeptide GHK (10). Next in order of magnitude in inducing cytogenetic effects is 2-amino-1,4-naphthoquinone (2) and its coupling products with glycine and serine (4 and 5), while the rest displayed marginal activity.
点击下载:
PDF
(103KB)
返 回