Despite its rarity and advances in treatment and supportive care, cancer remains the leading cause of death from disease in children under 15. While the field of pediatric oncology has seen some advances in diagnostic and treatment techniques, researchers continue to face numerous hurdles in determining causative factors associated with childhood cancer. One of the most hotly contested issues in this area is the possible link between childhood cancer and environmental toxins. This article presents an interview with three pediatric oncologists and an environmental research toxicologist to help provide insight into the relationship between environmental exposures and childhood cancer.