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Diminished Plasma Levels of Vitamin E in Patients with Severe Viral Hepatitis

 

作者: HerbayAlexandra Von,   StahlWilhelm,   NiederauClaus,   LaarJutta Von,   StrohmeyerGeorg,   SiesHelmut,  

 

期刊: Free Radical Research  （Taylor Available online 1996）
卷期: Volume 25, issue 6  

页码: 461-466

 

ISSN:1071-5762

 

年代: 1996

 

DOI:10.3109/10715769609149068

 

出版商: Taylor&Francis

 

关键词: Alpha-tocopherol;vitamin E;liver;viral hepatitis;free radicals;antioxidants;oxidative stress

 

数据来源: Taylor

 

摘要:

RRR-alpha-Tocopherol (Vitamin E) was assayed in plasma of 48 patients with viral hepatitis and of 32 healthy controls. In patients with highly elevated serum transaminases (ALT<100 U/L) vitamin E plasma levels were significantly lower (17.5±4.8μmol/L) than in controls (22.7±4.2μmol/L, p<0.01). The vitamin E/ lipid ratios (3.12±0.63μmol/g) in these patients were 33% lower than those of the controls (4.68±0.54μmol/g). The lowered vitamin E levels in patients with acute or chronic viral hepatitis with high activity of disease may be due to free radical-mediated liver injury.

 

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