Blood Concentration and Urinary Excretion of Captopril (SQ 14,225) in Patients with Chronic Renal Failure
作者:
KAORU ONOYAMA,
HIDEKI HIRAKATA,
KUNITOSHI ISEKI,
SATORU FUJIMI,
TERUO OMAE,
MASAKI KOBAYASHI,
YUKINORl KAWAHARA,
期刊:
Hypertension
(OVID Available online 1981)
卷期:
Volume 3,
issue 4
页码: 456-459
ISSN:0194-911X
年代: 1981
出版商: OVID
关键词: KEYWORDS;blood concentration;pharmacoklnetics;chronic renal failure;captopril urinary excretion
数据来源: OVID
摘要:
SUMMARY Blood concentration and urinary excretion of captopril following SO mg oral administration were determined by high-performance liquid chromatography In normal subjects and patients with chronic renal failure. In normal subjects, the iwrimum blood concentration of the free form of captopril was obtained − within 1 hour and was not detectable after 6 hours; 41% of administered captopril was excreted into the urine as free form and metabolites within 2 hours, and 58% within 6 hours. In chronic renal failure patients with an average serum creatinine of 5.1 mg/dl, the absorption constant (Ka), maximum concentration (Cmax), and area under the blood concentration curre (AUC) were not significantly different from those in the normal subjects, but the elimination constant (Ke) and biological half-life (T1/t) showed a significant delay in the disappearance of captopril from the blood (p< 0.01 respectively). The cumulatire amount of urinary excretion of either free-form captopril or its' metabolites was significantly decreased at 2,4, and 6 hours in chronic renal failure patients (p< 0.01 or less, respectively). Impairment of kidney function is suggested to be an important factor In the promotion of blood retention of captopril.
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