ASSESSMENT OF RED BLOOD CELL DEFORMABILITY BY CENTRIFUGAL SEDIMENTATION
作者:
ARIELA ALBALAK,
SARA STREICHMAN,
ABRAHAM MARMUR,
期刊:
Chemical Engineering Communications
(Taylor Available online 1996)
卷期:
Volume 152-153,
issue 1
页码: 5-15
ISSN:0098-6445
年代: 1996
DOI:10.1080/00986449608936552
出版商: Taylor & Francis Group
关键词: Red blood cells;Deformability;Sedimentation;Centrifugal
数据来源: Taylor
摘要:
A centrifugal sedimentation method (CSM) is proposed for the assessment of deformability of red blood cells. The method is based on the premise that a red blood cell (RBC) should deform in a centrifugal field due to the variation of the centrifugal acceleration with the distance from the center of rotation. This change in shape of the RBC leads to a change in the rate of sedimentation in the centrifugal field. The rate of sedimentation, which serves as a measure of deformability, is characterized by an apparent sedimentation coefficient (ASC) and its normalized value (NASC), which is calculated by comparison with a control group of normal RBCs. It has been shown that the NASC is sensitive to the speed of rotation, to treatments with glutaraldehyde, diamide, or chlorpromazine, to heat treatment and to osmotic pressure variations.
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