Insulin-Dependent Diabetes Mellitus Associated with Autoimmune Thyroiditis and Rheumatoid Arthritis
作者:
Eiji Yamato,
Hiroshi Ikegami,
Yoshihiko Kawaguchi,
Tomomi Fujisawa,
Yoichi Hamada,
Hironori Ueda,
Maki Shintani,
Toshio Ogihara,
期刊:
The American Journal of the Medical Sciences
(OVID Available online 1997)
卷期:
Volume 313,
issue 1
页码: 64-66
ISSN:0002-9629
年代: 1997
出版商: OVID
关键词: Insulin-dependent diabetes mellitus;Autoimmune thyroiditis;Rheumatoid arthritis
数据来源: OVID
摘要:
A case associated with insulin-dependent diabetes mellitus (IDDM), rheumatoid arthritis (RA), and autoimmune thyroid disease (AITD) was reported. A high titer of antiglutamic acid decarboxylase antibody (GAD) and a positive islet cell antigen were observed. The patient's human leukocyte antibody (HLA) haplotype was a homozygote of DQA1*0301, DQB1*0401, and DRB1*0405. Because this haplotype was in linkage disequilibrium with DPB1*0501, an allele associated with AITD in Japanese patients, the patient was homozygous for alleles susceptible to IDDM, RA, and AITD. A specific HLA haplotype susceptible to several autoimmune disease may result in the development of IDDM, RA, and AITD.
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