Effect of chelating agent structure on the mobilization of cadmium from intracellular deposits
作者:
PramodK. Singh,
MarkM. Jones,
ShirleyG. Jones,
GlenR. Gale,
LorettaM. Atkins,
AlayneB. Smith,
RobertA. Bulman,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1989)
卷期:
Volume 28,
issue 4
页码: 501-518
ISSN:0098-4108
年代: 1989
DOI:10.1080/15287398909531367
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
An examination of the efficacy of several structural types of chelating agents in the removal of cadmium from its intracellular deposits in mouse liver and kidneys reveals that of the structural types examined, only dithiocarbamates and a vicinal dithiol were able to mobilize cadmium from such intracellular sites. Esters of L‐cysteine, a macrocyclic thioether, and a disulfide of a dithiocarbamate were unable to cause any appreciable decrease in either renal or hepatic cadmium levels. Charged groups such as car‐boxylic acid groups reduce the efficacy as well as the toxicity of the structural types that can otherwise mobilize such cadmium. It was also found that the administration of a cadmium‐binding polymer ip leads to only a very slight net excretion of cadmium, while the po administration of this polymer leads to no net additional cadmium excretion. Of the compounds newly reported here, some are approximately equal in cadmium‐mobilizing efficacy to the most effective of previously reported compounds.
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