Action of Luteinizing Hormone-Releasing Factor (LRF) in the Initiation of Lordosis Behavior in the Estrone-Primed Ovariectomized Female Rat
作者:
R.L. Moss,
S.M. McCann,
期刊:
Neuroendocrinology
(Karger Available online 1975)
卷期:
Volume 17,
issue 4
页码: 309-318
ISSN:0028-3835
年代: 1975
DOI:10.1159/000122369
出版商: S. Karger AG
关键词: Luteinizing hormone-releasing factor;Lordosis behavior;Ejaculation;Gonadotropins;Ovarian hormones
数据来源: Karger
摘要:
In order to evaluate the precise role of luteinizing hormone-releasing factor (LRF) in mediating the onset of sexual behavior, the specificity, time-course, and dose-response relationship of LRF-facilitated lordosis behavior were determined. Ovariectomized female rats, pretreated with estrone and LRF, displayed a pattern of lordosis behavior which differed little from that produced by estrone-progesterone. Little if any lordosis behavior was observed in response to LRF alone, estrone alone, or estrone in combination with luteinizing hormone (LH), follicle-stimulating hormone (FSH), or thyrotropin-releasing factor (TRF). Furthermore, LRF-induced lordosis behavior occurred in the absence of the adrenals, thus eliminating adrenal progesterone as a factor in facilitating the appearance of lordosis behavior. The LRF-facilitated lordosis behavior was seen 2 h after the injection of LRF and was maintained for a total of 8 h. A minimal dose of 150 ng LRF was required to initiate the first consistent appearance of lordosis behavior; the maximum response was obtained with 500 ng. It is thus suggested that LRF is not only responsible for the ovulatory discharge of LH and subsequent ovulation, but may also play a role in the initiation of the onset of mating behavior in the female rat.
点击下载:
PDF
(1136KB)
返 回