Influence of dynamic contact of hard contact lens materials on corneal epithelial cells examined by rose bengal staining
作者:
IguchiIkuo,
KamiyamaKenji,
ImamichiMasatsugu,
OhashiToshio,
HeJiucheng,
WangXiaoguang,
ImanishiJiro,
期刊:
Current Eye Research
(Taylor Available online 1996)
卷期:
Volume 15,
issue 6
页码: 647-652
ISSN:0271-3683
年代: 1996
DOI:10.3109/02713689609008905
出版商: Taylor&Francis
关键词: Corneal epithelial cell;Corneal endothelial cell;Dry eye syndrome (keratoconjunctivitis sicca);dynamic contact;hard contact lens;rose bengal;pig
数据来源: Taylor
摘要:
Purpose. To establish a method for evaluation of less irritating contact lens materials by dynamic contact with cornea, we examined epithelial and endothelial cell injury to the porcine cornea caused by rotatory rubbing with four kinds of hard contact lenses (HCL).Methods. The HCLs used were (1) polymethylmethacrylate (PMMA) HCL, (2) gas-permeable HCL composed of a graft co-polymer of dextran derivative and methylmethacrylate (MMA) (Suncon Mild II™, 12 Dk), (3) gas-permeable HCL composed of a graft co-polymer of dextran derivative, a monomer containing silicone, a monomer containing fluorine and MMA (New Dx HCL-136, 32 Dk), and (4) gas-permeable HCL composed of a monomer containing silicone, a monomer containing fluorine and MMA (RGPL-A, 216 Dk). Using a specially designed apparatus, we produced a standardized injury to the epithelium or endothelium of porcine corneas by holding the HCL against the corneal surface while rotating the lens rapidly.Results. After rotatory rubbing of the HCL on the epithelium, the degree of rose bengal staining of the epithelial cells, indicating degeneration of the cells and mucin detachment, were significantly different among these HCLs (New Dx HCL-136
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