PurposeTo assess the efficacy of intraoperative mitomycin C in improving the success rate of the posterior punctectomy procedure.MethodsThe charts of all patients who underwent posterior punctectomy between the years 1997 and 2000 were reviewed. The procedure was done without mitomycin C (n = 26 eyes, group A) until the end of 1998 and with mitomycin C (n = 25 eyes, group B) starting in 1999. The Kaplan-Meier curve was used for statistical evaluation.ResultsIn group A, 5 of 26 (19.2%) eyes had complete anatomic obstruction and scarring of their puncta after surgery, compared with 0 of 25 (0.0%) eyes in group B. The difference was statistically significant (P<0.02). No significant complications were observed.ConclusionsMitomycin C appears to be a safe and effective adjunct therapy in correcting punctal stenosis.