Nelson's SyndromeOne Disease or Two?
作者:
Michael Saleman,
Julio Garcia,
Douglas Abbott,
Luis Martin,
期刊:
Neurosurgery
(OVID Available online 1979)
卷期:
Volume 5,
issue 4
页码: 480-484
ISSN:0148-396X
年代: 1979
出版商: OVID
关键词: Adrenocorticotropic hormone;Cushing's disease;Hypophysectomy;Nelson's syndrome;Pituitary tumors
数据来源: OVID
摘要:
&NA;We present a case of Nelson's syndrome in which the clinical, radiographic, and surgical findings are indicative of a discrete microadenoma rather than of diffuse pituitary hyperplasia. Ultrastructural analysis reveals this to be the first example of a sparsely granulated lesion in Nelson's syndrome and only the second such adrenocorticotropic hormonesecreting tumor reported. Unfortunately, there do not seem to be any firm ultrastructural features that differentiate between hyperplasia and discrete adenoma. Separation of the two entities may be important in delineating the pathogenesis and treatment of Nelson's syndrome; these are discussed.
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