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Problems in evaluating chronic toxicity of contraceptive steroids in dogs

 

作者: JohnH. Weikel,   LaurnieW. Nelson,  

 

期刊: Journal of Toxicology and Environmental Health  (Taylor Available online 1977)
卷期: Volume 3, issue 1-2  

页码: 167-177

 

ISSN:0098-4108

 

年代: 1977

 

DOI:10.1080/15287397709529556

 

出版商: Taylor & Francis Group

 

数据来源: Taylor

 

摘要:

The long‐term effects of oral contraceptive steroids including a combination of norethindrone and ethynylestradiol, a sequential regimen of dimethisterone and ethynylestradiol, and daily administration of megestrol acetate were studied in female beagle dogs at dose levels of 1, 10, or 25 times the projected human dose levels.

 

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