Endomorphins have orexigenic and anxiolytic activities in mice
作者:
Akihiro Asakawa,
Akio Inui,
Kazuhiro Momose,
Naohiko Ueno,
Masayuki Fujino,
Masato Kasuga,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 10
页码: 2265-2267
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Anxiolytic;Endomorphins 1 and 2;Feeding;Intracerebroventricular;Mice;μ-Opioid receptor
数据来源: OVID
摘要:
THIS study was designed to investigate the effects of endomorphin 1 and 2, recently identified μ-opioid receptor selective peptides, on food intake and anxiety in non-food-deprived mice. The intracerebroventricular (i.c.v.) injection of either endomorphin 1 or 2 (0.03–30 nmol) increased food intake in a dose-related manner. A significant increase was observed 20 min after i.c.v. injection of endomorphin 1 or 2 and continued for 4 h. In the elevated plus maze test, the i.c.v. injection of endomorphin 1 (30 nmol) significantly decreased the normal preference for the closed arms. These results suggest that endomorphin produces orexigenic and anxiolytic effects, and that the μ-opioid receptor contributes to the regulation of feeding and anxiety in mice.
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