Effects of Imipramine on Chromosomes in Psychiatric Patients
作者:
Tsu-Ker Fu,
Lissy F. Jarvik,
Fu-Sun Yen,
Steven S. Matsuyama,
Alexander H. Glassman,
James M. Perel,
Sidney Maltiz,
期刊:
Neuropsychobiology
(Karger Available online 1978)
卷期:
Volume 4,
issue 2
页码: 113-120
ISSN:0302-282X
年代: 1978
DOI:10.1159/000117625
出版商: S. Karger AG
关键词: Antidepressant;Chromosomes;Depression;Imipramine
数据来源: Karger
摘要:
25 patients with primary depression receiving therapeutic doses of imipramine showed no increase in chromosome abnormalities (either breaks or aneuploidy) when frequencies before and after initiation of imipramine therapy were compared. These results are in accord with previous in vitro findings showing an effect of imipramine on cell proliferation but not on frequency of chromosomal abnormalities.
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