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Effects of Imipramine on Chromosomes in Psychiatric Patients

 

作者: Tsu-Ker Fu,   Lissy F. Jarvik,   Fu-Sun Yen,   Steven S. Matsuyama,   Alexander H. Glassman,   James M. Perel,   Sidney Maltiz,  

 

期刊: Neuropsychobiology  (Karger Available online 1978)
卷期: Volume 4, issue 2  

页码: 113-120

 

ISSN:0302-282X

 

年代: 1978

 

DOI:10.1159/000117625

 

出版商: S. Karger AG

 

关键词: Antidepressant;Chromosomes;Depression;Imipramine

 

数据来源: Karger

 

摘要:

25 patients with primary depression receiving therapeutic doses of imipramine showed no increase in chromosome abnormalities (either breaks or aneuploidy) when frequencies before and after initiation of imipramine therapy were compared. These results are in accord with previous in vitro findings showing an effect of imipramine on cell proliferation but not on frequency of chromosomal abnormalities.

 

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