AbstractAre different messenger RNA species translated in distinct, limited domains within a cell? For the particular case of the giant R2 neuron fromAplysia californicaan answer to this question is possible for the more abundantly synthesized proteins. After brief labeling with35S‐methionine, the R2 neuron soma was frozen and divided into two or three parts. The newly synthesized proteins were analyzed following two‐dimensional polyacrylamide gel electrophoresis. No evidence for limited domains of synthesis for 26 abundantly synthesized polypeptides in the R2 neuron was fo