Influence of Dietary Sodium on Blood Pressure in Baroreceptor‐Denervated Rats
作者:
Peter Howe,
Paul Rogers,
Jane Minson,
期刊:
Journal of Hypertension
(OVID Available online 1985)
卷期:
Volume 3,
issue 5
页码: 457-460
ISSN:0263-6352
年代: 1985
出版商: OVID
关键词: Sino-aortic denervation;baroreceptors;salt sensitivity;neurogenic hypertension
数据来源: OVID
摘要:
One possible explanation for the salt sensitivity of blood pressure (BP) in certain hypertensive individuals is that neural mechanisms which normally counteract the pressor effect of a high dietary sodium intake are defective. We have tested this possibility in normotensive Wistar-Kyoto rats (WKY) by surgically ablating the arterial baroreflex mechanism. This manoeuvre, by itself, conferred substantial salt-sensitivity on the WKY rats whose BP is normally relatively insensitive to dietary sodium intake. The treated rats responded to a high sodium diet with a significant rise in systolic BP which was reversed by substituting a low sodium diet. Thus, impaired baroreflex function which has been observed in essential hypertension and in hypertensive animals, may be responsible for the hypertensive effect of sodium.
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