Experimental studies on benzene carcinogenicity at the bologna institute of oncology: Current results and ongoing research
作者:
Cesare Maltoni,
Barbara Conti,
Giuliano Cotti,
Fiorella Belpoggi,
期刊:
American Journal of Industrial Medicine
(WILEY Available online 1985)
卷期:
Volume 7,
issue 5‐6
页码: 415-446
ISSN:0271-3586
年代: 1985
DOI:10.1002/ajim.4700070508
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: benzene;benzene‐correlated aromatics;carcinogenicity bioassay;ethyl‐benzene;multipotential carcinogens;toluene;xylene
数据来源: WILEY
摘要:
AbstractIn 1977 Maltoni and Scarnato were the first to demonstrate that benzene is an experimental carcinogen in rats. With that and other experiments, Maltoni et al have shown that benzene administered by ingestion (stomach tube) or inhalation is a multipotential carcinogen in rats (of two different strains) and mice and produces a variety of tumors, namely: Zymbal gland carcinomas, oral and nasal cavity carcinomas, skin carcinomas, acanthomas, dysplasias and carcinomas of forestomach, mammary malignant tumors, hepatomas, liver angiosarcomas, hemolymphoreticular neoplasias, and pulmonary tumors. The incidence of Zymbal gland carcinomas and carcinomas of the oral and nasal cavitities is affected by the length of treatment by inhalation and by the age of animals. However, the available epidemiological and experimental data at present do not provide precise information on the risk of doses around or below 10 ppm. Long‐term carcinogenicity bioassays at 50, 25, 10, 5 and 1 ppm may be helpful for scientific risk assessment. In addition, these experiments have shown that toluene, xylene, and ethylbenzene, at high concentrations, cause an increase in the number of total malignant tumor
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