Severe Cardiotoxicity During 5-Fluorouracil ChemotherapyA Case and Literature Report
作者:
Christiane Kuropkat,
Katherine Griem,
James Clark,
E. Rodriguez,
James Hutchinson,
Samuel Taylor,
期刊:
American Journal of Clinical Oncology: Cancer Clinical Trials
(OVID Available online 1999)
卷期:
Volume 22,
issue 5
页码: 466-466
ISSN:0277-3732
年代: 1999
出版商: OVID
关键词: 5-Fluorouracil;Chemotherapy;Cardiotoxicity;Pathogenesis;Head and neck cancer.
数据来源: OVID
摘要:
The chemotherapeutic agent 5-fluorouracil (5-FU) is a widely accepted part of many cancer treatment protocols. Its cardiotoxic potential is known, but considered uncommon and usually not life threatening, although some cases of severe cardiotoxicity related to 5-FU have been reported. The pathogenesis of cardiotoxicity caused by 5-FU is not clear. We report a case of sudden onset of severe cardiac failure, without ischemic symptoms or signs, during 5-FU treatment with serious consequences, in a previously healthy 23-year-old patient with squamous cell carcinoma of the tongue. Endomyocardial biopsy showed proliferation of the sarcoplasmic reticulum with marked vacuolization, similar to that found with doxorubicin cardiotoxicity. Because 5-FU cardiotoxicity is unpredictable and can have potentially fatal consequences, it requires, in our opinion, further clarification. With this well-documented case, including an endomyocardial biopsy, we hope to encourage additional efforts to investigate the pathophysiologic mechanisms of 5-FU cardiotoxicity.
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