AbstractFrom the whole body of sea cucumberCucumaria echinata(Cucumariidae), we recently identified six genuine holostane‐type triterpenoid glycoside sulfates designated as cucumechinoside A (1), B (2), C (3), D (4), E (5), and F (6). The structures1–6were determined on the basis of chemical and spectral investigations. Antitumor activities of these cucumechinosides and their solvolized compounds (10,11, and12) against murine lymphoma L 1210 and human epidermoid carcinoma KB cell in vitro were examined, and their antifungal and antiprotozoal activities were also investiga