Simultaneous Multivariate Spectrophotometric Analysis of Binary and Ternary Mixtures of Sulfamethoxazole, Trimethoprim and Phenazopyridine in Tablets
作者:
María Eí Ribone,
Ariana P. Pagani,
Alejandro C. Olivieri,
期刊:
Analytical Letters
(Taylor Available online 1999)
卷期:
Volume 32,
issue 7
页码: 1389-1401
ISSN:0003-2719
年代: 1999
DOI:10.1080/00032719908542905
出版商: Taylor & Francis Group
关键词: Absorption spectrophotometry;Multivariate calibration;Partial least-squares;Sulfamethoxazole;Trimethoprim;Phenazopyridine
数据来源: Taylor
摘要:
The use of multivariate spectrophotometric calibration is reported for the analysis of tablets containing the antibiotics sulfamethoxazole and trimethoprim, and a combination of the former two drugs with the analgesic phenazopyridine. The resolution of these mixtures has been accomplished without prior separation, derivatisation or use of nonaqueous solvents, with the aid of partial least-squares (PLS-1) regression analysis of electronic absorption spectral data. The analytes have been simultaneously determined with high accuracy and precision, and with no interference from tablet excipients.
点击下载:
PDF (369KB)
返 回