Perinatal Rat Lung Retinol (Vitamin A) and Retinyl Palmitate
作者:
RICHARD ZACHMAN,
BHARATI KAKKAD,
FRANK CHYTIL,
期刊:
Pediatric Research
(OVID Available online 1984)
卷期:
Volume 18,
issue 12
页码: 1297-1299
ISSN:0031-3998
年代: 1984
出版商: OVID
数据来源: OVID
摘要:
The potential role for retinol (vitamin A alcohol) in the differentiation of the developing lung prompted this study in the perinatal rat. High performance liquid chromatography was used to separate, detect, and quantitate retinol and retinyl palmitate in lipid extracts of tissue and serum. Fetal and maternal blood showed the presence of retinol, whereas no retinyl palmitate was detected. On the other hand, fetal and postnatal lungs contained retinyl palmitate as well as retinol. Considerable changes in the content of lung retinyl palmitate were found during lung development. Fetal lungs (17-21 days of gestation) contained 2.3 ± 0.36 µg/g wet weight (mean ± SD) of retinyl palmitate and 0.14 ± 0.05 µg/g of retinol. Lungs of pups (1-10 days old) contained much less retinyl palmitate, 0.63 ± 0.20 µg/g, whereas the amount of retinol was the same as in fetal lungs. The surprisingly high content of retinyl palmitate in fetal lung and its depletion after birth may be functionally related to retinol action in the developing lung.
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