Mutagenicity of particulate emissions from the M16 rifle: Variation with particle size
作者:
WinifredG. Palmer,
A. W. Andrews,
Donna Mellini,
JosephA. Terra,
FlorenceJ. Hoffmann,
StevenH. Hoke,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1994)
卷期:
Volume 42,
issue 4
页码: 423-433
ISSN:0098-4108
年代: 1994
DOI:10.1080/15287399409531892
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Emissions generated by firing the M16 rifle with the propellant WC844 in a combustion chamber designed to simulate conditions of actual use were tested for mutagenic activity in the Salmonella/Ames assay. Dimethyl sulfoxide extracts of emissions collected from either the breech or muzzle end of the rifle were mutagenic in three strains of Salmonella (TA1537, TA1538, and TA98) both in the presence and absence of metabolic activation systems (59). The extracts were negative in strains TA100 and TA102. Aerosols generated by firing the M16 rifle were fractionated according to aerodynamic diameter. Sub‐micrometer particles were far more mutagenic than particles with aerodynamic diameters between 1 and 15 μm. The mutagens associated with the smaller particles were more active in the presence of S9, while extracts of larger particles were as active, or more active, in the absence of 59. Heavier particles, which settled rapidly out of the airstream, were not mutagenic.
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