Immunohistochemical localization of c‐myc oncogene product and EGF receptor in oral squamous cell carcinoma
作者:
Hidetaka Sakai,
Kenji Kawano,
Kazuhiko Okamura,
Norizo Hashimoto,
期刊:
Journal of Oral Pathology&Medicine
(WILEY Available online 1990)
卷期:
Volume 19,
issue 1
页码: 1-4
ISSN:0904-2512
年代: 1990
DOI:10.1111/j.1600-0714.1990.tb00773.x
出版商: Blackwell Publishing Ltd
关键词: c‐myc;EGF receptor;immunohistochemy;oral squamous cell carcinoma
数据来源: WILEY
摘要:
Subcellular distribution of c‐myc oncogene product and EGF receptor in oral squamous cell carcinomas was examined by using immunohistochemical method. Immunohistochemy for c‐myc oncogene showed three staining patterns. Reactive products were demonstrable in the nucleus, in the perinuclear cytoplasm with granular appearance and in the entire cytoplasm. Concomitant stainings of each reactive pattern were observed. Occasionally, the reactive product was strongly deposited on the chromatin under mitotic phase. EGF receptor positive cases were found in only 4 of 28 cases. Though reactive products were usually found in the cytoplasm, the cell surface staining was detected in the only one case. In this case, cells under mitotic phase were strongly stained. The fact that the strong staining both of c‐myc and EGF receptor in cells under mitotic phase suggested the close relation between the expression of these genes and the proliferation of carcinoma
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