Identification of mammalian GR α‐2 splice isoforms
作者:
Y Wong,
H Too,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 17
页码: 3767-3773
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: GDNF family receptor a (GFRα);Neurturin receptor (GFRα-2);Reverse transcription-PCR (RT-PCR);Splice isoforms
数据来源: OVID
摘要:
NEURTURIN (NTN) belongs to a structurally related family of bioactive molecules which include glial cell-line derived neutrotrophic factor (GDNF) and perserphin (PSP). NTN exerts its effects through a multicomponent receptor system which include a receptor (GFRα-2) and the proto-oncogene c-RET. We report here the identification of three splice isoforms of the GFRα-2 receptors (GFRα-2a, GFRα-2b and GFRα-2c) by reverse transcription-PCR (RT-PCR). GFRα-2b is a novel splice variant. All three isoforms were found to be expressed in various adult murine tissues as well as in the brain of the newborn human. The identity of these isoforms were further confirmed by the isolation of the gene and the characterisation of the splice junctions.
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