Biological activity and bioavailability of grain bound14C‐malathion residues in rats
作者:
M.A. Syed,
J.H. Arshad,
S. Mat,
期刊:
Journal of Environmental Science and Health, Part B
(Taylor Available online 1992)
卷期:
Volume 27,
issue 4
页码: 347-354
ISSN:0360-1234
年代: 1992
DOI:10.1080/03601239209372785
出版商: Taylor & Francis Group
关键词: Maize;Rice;14C‐malathion;Bound residues;Biological activity;Bioavailability
数据来源: Taylor
摘要:
Paddy (unmilled rice), milled rice and maize‐bound14C residues were prepared using14C‐succinate‐labelled malathion at 10 and 152 ppm. After 3 months, the bound residues accounted for 12%, 6.5% and 17.7% of the applied dose in paddy, milled rice and maize respectively in the grains treated at 10 ppm. The corresponding values for the 152 ppm were 16.6%, 8.5% and 18.8%. Rats fed milled rice ‐ bound14C‐residues eliminated 61% of the14C in the faeces and 28% in the urine. The corresponding percentages for paddy and maize were 72%, 9% and 53%, 41% respectively; indicating that bound residues from milled rice and maize were moderately bioavailable. When rice‐bound malathion residues (0.65 ppm in feed) were administered to rats in a 5 week feeding study, no signs of toxicity were observed. Plasma and RBC cholinesterase activities were slightly inhibited: blood urea nitrogen was significantly elevated in the test animals. Other parameters examined showed no or marginal changes.
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