Immunological and virological markers in individuals progressing from seroconversion to AIDS
作者:
Rob Gruters,
Fokke Terpstra,
Ruud De Goede,
Jan Mulder,
Frank Wolf,
Peter Schellekens,
René Van Lier,
Matthijs Tersmette,
Frank Miedema,
期刊:
AIDS
(OVID Available online 1991)
卷期:
Volume 5,
issue 7
页码: 837-844
ISSN:0269-9370
年代: 1991
出版商: OVID
关键词: T cells;virus variants;progression;CD4;immune function.
数据来源: OVID
摘要:
Six men were selected from a large cohort of homosexual men participating in a study on HIV infection that was followed from seroconversion to AIDS. The patients were studied retrospectively for immunological functions of T cells, T-cell subset distribution and biological phenotype of HIV. A severe decrease in anti-CD3 monoclonal antibody (MAb)-induced T-cell proliferation at seroconversion was observed in two out of six men. After this acute phase, CD4+ T-cell numbers were in the normal range in the early asymptomatic period; the proliferative response was subnormal, whereas the capacity to generate cytotoxic T cells (CTL) was normal. From seroconversion on, CD4 + CD29 + memory T-cell numbers were decreased to approximately 50% of normal values, which may contribute to loss of T-cell reactivity. In the asymptomatic phase only slow-replicating non-syncytium-inducing HIV variants were observed. The T-cell proliferative response further declined with the depletion of naive CD4 + CD45RA + T cells and CD4 + T -cell numbers started to decline. This second decrease in T-cell function coincided with the emergence of more rapidly replicating, often (four out of six) syncytium-inducing variants. At diagnosis of AIDS, T-cell proliferation and CD4+ T-cell numbers were extremely low in five out of six patients and CTL function had declined in three out of five individuals tested. Circulating CD8+ cells had gradually shifted to an immature CD38 + CD28− phenotype. Our findings support the theory that HIV-induced immune dysfunction allows for the emergence of virulent HIV variants associated with CD4+ cell loss and disease.
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