Hepatitis Delta Virus RNA Detection in Chronic HBsAg Carriers with and without HIV Infection
作者:
I. Castillo,
J. Bartolomé,
A. Madejón,
M. Melero,
J.C. Porres,
V. Carreño,
期刊:
Digestion
(Karger Available online 1991)
卷期:
Volume 48,
issue 3
页码: 149-156
ISSN:0012-2823
年代: 1991
DOI:10.1159/000200687
出版商: S. Karger AG
关键词: Hepatitis D virus;Human immunodeficiency virus;HBsAg;chronic carriers
数据来源: Karger
摘要:
Hepatitis delta virus (HDV) RNA detection was carried out, using a full-length HDV RNA probe, in serum of 43 patients with chronic HDV infection. Among them, 30 cases (70%) were HDV RNA-positive. With respect to other HDV markers, serum HDAg (detected by immunoblot) was found in 33 patients (77%) and IgM anti-HD in 29 (67%). A similar percentage of HDV RNA-positive patients with and without circulating hepatitis B virus (HBV) DNA (32.5 vs. 37%, respectively) was found. Antibodies against the human immunodeficiency virus (HIV) were detected in 15/43 subjects studied. The presence of HDV RNA was significantly higher (p < 0.05) in anti-HIV-seropositive cases (93%) than in the HIV-seronegative ones (57%). Moreover, simultaneous HDV and HBV replication was found more frequently (60 vs. 18%, p < 0.05) and at higher levels among the anti-HIV-positive patients than in the rest. In addition, in most of the anti-HIV-positive subjects, HDV RNA and HBV DNA were constantly positive during a whole year of follow-up.
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