Monoclonal antibodies as potentiators of radiotherapy and chemotherapy in the management of head and neck cancer
作者:
Richard Wheeler,
Sharon Spencer,
Donald Buchsbaum,
Francisco Robert,
期刊:
Current Opinion in Oncology
(OVID Available online 1999)
卷期:
Volume 11,
issue 3
页码: 187-187
ISSN:1040-8746
年代: 1999
出版商: OVID
数据来源: OVID
摘要:
The overall survival of patients with squamous cell cancer of the head and neck has not significantly improved over the past 2 decades. Preclinical studies suggest that combining a monoclonal antibody to the epidermal growth factor receptor with irradiation or chemotherapy agents active in squamous cell cancer of the head and neck could increase treatment efficacy. Completed phase I studies have shown these combinations to be both feasible and tolerable. Phase III studies are now beginning to establish firmly the efficacy of this innovative new approach.
返 回