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The Titrimetric Determination of 4-Pyridine Carboxylic Acid Hydrazide (Isoniazid) in Drug Formulations with Thallium (III)

 

作者: KrishnaK. Verma,   Sandhya Palod,  

 

期刊: Analytical Letters  （Taylor Available online 1985）
卷期: Volume 18, issue 1  

页码: 11-19

 

ISSN:0003-2719

 

年代: 1985

 

DOI:10.1080/00032718508066921

 

出版商: Taylor & Francis Group

 

关键词: Isoniazid Determination;Drug Formulations;Oxidation with Thallium(III);Titrimetry.

 

数据来源: Taylor

 

摘要:

Thallium (III) sulfate in dilute sulfuric acid quantitatively oxidizes isoniazid to nitrogen and 4-pyrldine carboxylic acid. The test material is reacted with a measured excess of the reagent, the residual amount being back-titrated with ascorbic acid using o-dianisidine or p-ethoxychrysoidine as indicator. 4-Aminosalicylic acid, thiacetazone, thiamine hydrochloride, lactose and a number of other excipients do not Interfere with the analysis.

 

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