The effects of Innovar on hemodynamics and blood gases were studied in IS adult patients with advanced cardiac disease during analgesia and sedation for angiocardiography. No significant changes in cardiac index or rate, stroke volume, stroke work, or left ventricular systolic and diastolic pressures were observed- Femoral systolic pressure decreased, on the average, from 152 to 139 mm Hg; femoral diastolic pressure, from 74 to 67 mm Hg; mean femoral pressure, from 100 to 91 mm Hg. Systemic vascular resistance decreased from 40.4 to 35.8 units, while pulmonary resistance did not change. Paco2increased from 35 to 40 mm Hg, whereas Paco2decreased from 76 to 57 mm Hg. All these changes were significant.