In field experiments conducted at the Nyankpala Agricultural Station, Ghana, during 1976–77, soil moisture conditions appeared to be the deciding factor in determining the frequency of handweeding needed to obtain maximum seed cotton yields. In 1976, when planting was early and the late, heavy rains in October prolonged weed growth, two handweedings at 4 and 8 weeks after seeding (w.a.s.) gave comparable yields to continuous weeding and significantly better yields than an alachlor + fluometuron herbicide mixture. Supplementary weeding did not enhance the mixture's performance.