Resynchronisation of a diurnal rodent circadian clock accelerated by a melatonin agonist
作者:
Olivier Van Reeth,
Elizabeth Olivares,
Fred Turek,
Laurent Granjon,
Elizabeth Mocaer,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 8
页码: 1901-1905
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Arvicanthis;Circadian clock phase shift;Diurnal rodent;Jet lag;Melatonin agonist
数据来源: OVID
摘要:
USING ‘jet lag’ paradigms involving phase shifts in the light-dark (LD) cycle, we studied the effects of S-20098 on the circadian clock of a diurnal rodent.Arvicanthis mordax, entrained to a regular LD cycle, were subjected to advance shifts (i.e. 4, 6 or 8 h) in the LD cycle and injected with vehicle or the melatonin agonist S-20098 (20 mg/kg) the day of the shift (and also on subsequent days in the 6 h or 8 h shift paradigms). In each condition, S-20098 accelerated by about 30% resynchronization to the new LD cycle. These data, which are the first to demonstrate the chronobiotic effects of a melatonin agonist in a diurnal rodent, provide new insights for the design of human chronopharmacological protocols.
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