Effects of ‘Central Hypervolemia’ by Water Immersion on Renin-Aldosterone System and ACTH-Cortisol Axis in Hemodialyzed Patients
作者:
P. Coruzzi,
A. Novarini,
L. Musiari,
E. Rossi,
A. Borghetti,
期刊:
Nephron
(Karger Available online 1984)
卷期:
Volume 36,
issue 4
页码: 238-241
ISSN:1660-8151
年代: 1984
DOI:10.1159/000183161
出版商: S. Karger AG
关键词: Water immersion;Low pressure receptors;Renin-aldosterone system;ACTH-cortisol axis;· Hemodialyzed patients
数据来源: Karger
摘要:
Water immersion up to the neck (WI) results in a central hypervolemia; the increased atrial pressure, evoked by this maneuver, stimulates low pressure receptors (LPR) which exert tonic inhibition on sympathetic activity and suppresses both the renin (PRA)-aldosterone (PA) system and the ACTH-cortisol axis in normal man. In hemodialyzed patients (HP), in whom autonomic neuropathy has been frequently found, PRA and ACTH were not suppressed during WI while plasma cortisol and PA were reduced. Other modulators, like dopamine, are supposed to be involved in regulating cortisol and PA levels in HP.
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