NCAM (CD56)-Positive Malignant Lymphoma
作者:
KernW. F.,
SpierC. M.,
MillerT. P.,
GroganT. M.,
期刊:
Leukemia&Lymphoma
(Taylor Available online 1993)
卷期:
Volume 12,
issue 1-2
页码: 1-10
ISSN:1042-8194
年代: 1993
DOI:10.3109/10428199309059565
出版商: Taylor&Francis
关键词: Malignant lymphoma;localization;cell adhesion molecules;neural cell adhesion molecule;CD56;polysialic acid
数据来源: Taylor
摘要:
CD56 has been found to identify an isoform of the neural cell adhesion (NCAM). NCAM is a member of the immunoglobulin superfamily of cell adhesion molecules; it is related to a variety of leukocyte antigens and to several cell adhesion molecules believed relevant to malignant behavior in a variety of neoplasms. It contains poly sialic acid, which appears to regulate binding avidity of NCAM and other cell adhesion processes.We have identified a group of NCAM-positive lymphomas. Compared to a group of NCAM-negative lymphomas, this group exhibited frequent involvement of unusual sites and a generally aggressive course. Another series of CD56-positive hematolymphoid malignancies has recently been described, from Hong Kong; this group also exhibited involvement of unusual sites and displayed a very aggressive course. Together these series suggest that NCAM on lymphoma is of biological and clinical significance in terms of tumor behavior and spread.
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