AbstractCondensation of L‐ and D‐3′‐amino‐2′,3′‐dideoxynucleosides2–5withN‐BOC‐protected aminoacids6and13using dicyclohexylcarbodiimide andN‐hydroxysuccinimide in DMF is reported to give theN‐BOC‐protected acylamino aminonucleosides 7–9and14in 51–81% yield. After deprotection using trifluoroacetic acid the corresponding unprotected new analogues of puromucin10–12and15were obtained in 43–56% yield. These compounds did not show any significant antiviral activity using HIV (stain HTLV‐III B)